Occupational health and safety in laboratories is a fundamental pillar to ensure a safe and stable working environment for both personnel and facilities. This commitment begins at the design stage, where compliance with technical standards and regulatory requirements must be embedded in the architectural and engineering plans of the laboratory. Appropriate fire protection and alarm systems should be selected based on the laboratory’s naturechemical, biological, or physical to ensure rapid response to potential hazards. The use of fire-resistant materials, safe ventilation layouts, and clearly defined emergency exits in accordance with NFPA and OSHA standards are essential components of this stage. During construction and commissioning, it is crucial to verify the correct installation and integration of all safety systems and engineering networks in line with approved technical specifications. Comprehensive testing and validation should be conducted to confirm operational reliability before handover. In the operational phase, laboratories must implement approved safety policies and ensure the continuous availability of personal protective equipment (PPE) for all personnel. Regular training programs should be conducted to enhance awareness and preparedness in managing potential risks. Finally, an on-site safety team should be designated to monitor compliance, conduct inspections, and ensure the sustainability of safe laboratory operations aligned with international best practices and occupational safety frameworks.